The malleable brain: plasticity of neural circuits and behavior - a review from students to students.
Identifieur interne : 000191 ( Main/Exploration ); précédent : 000190; suivant : 000192The malleable brain: plasticity of neural circuits and behavior - a review from students to students.
Auteurs : Natascha Schaefer [Allemagne] ; Carola Rotermund [Allemagne] ; Eva-Maria Blumrich [Allemagne] ; Mychael V. Lourenco [Brésil] ; Pooja Joshi [France] ; Regina U. Hegemann [Nouvelle-Zélande] ; Sumit Jamwal [Inde] ; Nilufar Ali [États-Unis] ; Ezra Michelet García Romero [Mexique] ; Sorabh Sharma [Inde] ; Shampa Ghosh [Inde] ; Jitendra K. Sinha [Inde] ; Hannah Loke [Australie] ; Vishal Jain [Inde] ; Katarzyna Lepeta [Pologne] ; Ahmad Salamian [Pologne] ; Mahima Sharma [Singapour] ; Mojtaba Golpich [Malaisie] ; Katarzyna Nawrotek [Pologne] ; Ramesh K. Paidi [Inde] ; Sheila M. Shahidzadeh [États-Unis] ; Tetsade Piermartiri [Brésil] ; Elham Amini [Malaisie] ; Veronica Pastor [Argentine] ; Yvette Wilson [Australie] ; Philip A. Adeniyi [Nigeria] ; Ashok K. Datusalia [Inde] ; Benham Vafadari [Pologne] ; Vedangana Saini [États-Unis] ; Edna Suárez-Pozos [Mexique] ; Neetu Kushwah [Inde] ; Paula Fontanet [Argentine] ; Anthony J. Turner [Royaume-Uni]Source :
- Journal of neurochemistry [ 1471-4159 ] ; 2017.
Abstract
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation and long-term depression, respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity. This review originated from the first International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Alpbach, Austria (Sep 2016), and will use its curriculum and discussions as a framework to review some of the current knowledge in the field of synaptic plasticity. First, we describe the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages. We then outline the signaling cascades resulting in the synthesis of new plasticity-related proteins, which ultimately enable sustained changes in synaptic strength. Going beyond the traditional understanding of synaptic plasticity conceptualized by long-term potentiation and long-term depression, we discuss system-wide modifications and recently unveiled homeostatic mechanisms, such as synaptic scaling. Finally, we describe the neural circuits and synaptic plasticity mechanisms driving associative memory and motor learning. Evidence summarized in this review provides a current view of synaptic plasticity in its various forms, offers new insights into the underlying mechanisms and behavioral relevance, and provides directions for future research in the field of synaptic plasticity. Read the Editorial Highlight for this article on doi: 10.1111/jnc.14102.
DOI: 10.1111/jnc.14107
PubMed: 28632905
Affiliations:
- Allemagne, Argentine, Australie, Brésil, France, Inde, Malaisie, Mexique, Nigeria, Nouvelle-Zélande, Pologne, Royaume-Uni, Singapour, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, Brême (Land), District de Basse-Franconie, District de Tübingen, Géorgie (États-Unis), Nebraska, Victoria (État), Yorkshire-et-Humber, État de New York, État de Rio de Janeiro, Île-de-France
- Brême, Leeds, Melbourne, Paris, Rio de Janeiro, Tübingen, Wurtzbourg
- Université de Leeds, Université de Melbourne, Université nationale de Singapour
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Paidi</name><affiliation wicri:level="1"><nlm:affiliation>CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata</wicri:regionArea><wicri:noRegion>Kolkata</wicri:noRegion></affiliation></author><author><name sortKey="Shahidzadeh, Sheila M" sort="Shahidzadeh, Sheila M" uniqKey="Shahidzadeh S" first="Sheila M" last="Shahidzadeh">Sheila M. Shahidzadeh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Piermartiri, Tetsade" sort="Piermartiri, Tetsade" uniqKey="Piermartiri T" first="Tetsade" last="Piermartiri">Tetsade Piermartiri</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina (UFSC), Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Amini, Elham" sort="Amini, Elham" uniqKey="Amini E" first="Elham" last="Amini">Elham Amini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Kebangsaan Malaysia Medical Centre (HUKM), Cheras, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine, University Kebangsaan Malaysia Medical Centre (HUKM), Cheras, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Pastor, Veronica" sort="Pastor, Veronica" uniqKey="Pastor V" first="Veronica" last="Pastor">Veronica Pastor</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Biología Celular y Neurociencia Prof. Eduardo De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Biología Celular y Neurociencia Prof. Eduardo De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Yvette" sort="Wilson, Yvette" uniqKey="Wilson Y" first="Yvette" last="Wilson">Yvette Wilson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Adeniyi, Philip A" sort="Adeniyi, Philip A" uniqKey="Adeniyi P" first="Philip A" last="Adeniyi">Philip A. Adeniyi</name><affiliation wicri:level="1"><nlm:affiliation>Cell Biology and Neurotoxicity Unit, Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado - Ekiti, Ekiti State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Cell Biology and Neurotoxicity Unit, Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado - Ekiti, Ekiti State</wicri:regionArea><wicri:noRegion>Ekiti State</wicri:noRegion></affiliation></author><author><name sortKey="Datusalia, Ashok K" sort="Datusalia, Ashok K" uniqKey="Datusalia A" first="Ashok K" last="Datusalia">Ashok K. Datusalia</name><affiliation wicri:level="1"><nlm:affiliation>National Brain Research Centre, Gurugram, Haryana, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>National Brain Research Centre, Gurugram, Haryana</wicri:regionArea><wicri:noRegion>Haryana</wicri:noRegion></affiliation></author><author><name sortKey="Vafadari, Benham" sort="Vafadari, Benham" uniqKey="Vafadari B" first="Benham" last="Vafadari">Benham Vafadari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Saini, Vedangana" sort="Saini, Vedangana" uniqKey="Saini V" first="Vedangana" last="Saini">Vedangana Saini</name><affiliation wicri:level="2"><nlm:affiliation>Department of Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska</wicri:regionArea><placeName><region type="state">Nebraska</region></placeName></affiliation></author><author><name sortKey="Suarez Pozos, Edna" sort="Suarez Pozos, Edna" uniqKey="Suarez Pozos E" first="Edna" last="Suárez-Pozos">Edna Suárez-Pozos</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Toxicología, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Toxicología</wicri:regionArea><wicri:noRegion>Toxicología</wicri:noRegion></affiliation></author><author><name sortKey="Kushwah, Neetu" sort="Kushwah, Neetu" uniqKey="Kushwah N" first="Neetu" last="Kushwah">Neetu Kushwah</name><affiliation wicri:level="1"><nlm:affiliation>Defence Institute of Physiology and Allied Sciences, Delhi, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Defence Institute of Physiology and Allied Sciences, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Fontanet, Paula" sort="Fontanet, Paula" uniqKey="Fontanet P" first="Paula" last="Fontanet">Paula Fontanet</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular and Cellular Neuroscience, Institute of Cellular Biology and Neuroscience (IBCN), CONICET-UBA, School of Medicine, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Division of Molecular and Cellular Neuroscience, Institute of Cellular Biology and Neuroscience (IBCN), CONICET-UBA, School of Medicine, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Turner, Anthony J" sort="Turner, Anthony J" uniqKey="Turner A" first="Anthony J" last="Turner">Anthony J. Turner</name><affiliation wicri:level="4"><nlm:affiliation>School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28632905</idno><idno type="pmid">28632905</idno><idno type="doi">10.1111/jnc.14107</idno><idno type="wicri:Area/PubMed/Corpus">000A19</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A19</idno><idno type="wicri:Area/PubMed/Curation">000A16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A16</idno><idno type="wicri:Area/PubMed/Checkpoint">000A16</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A16</idno><idno type="wicri:Area/Ncbi/Merge">004A14</idno><idno type="wicri:Area/Ncbi/Curation">004A14</idno><idno type="wicri:Area/Ncbi/Checkpoint">004A14</idno><idno type="wicri:Area/Main/Merge">000186</idno><idno type="wicri:Area/Main/Curation">000191</idno><idno type="wicri:Area/Main/Exploration">000191</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The malleable brain: plasticity of neural circuits and behavior - a review from students to students.</title><author><name sortKey="Schaefer, Natascha" sort="Schaefer, Natascha" uniqKey="Schaefer N" first="Natascha" last="Schaefer">Natascha Schaefer</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical Neurobiology, Julius-Maximilians-University of Wuerzburg, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical Neurobiology, Julius-Maximilians-University of Wuerzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Rotermund, Carola" sort="Rotermund, Carola" uniqKey="Rotermund C" first="Carola" last="Rotermund">Carola Rotermund</name><affiliation wicri:level="3"><nlm:affiliation>German Center of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center of Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Blumrich, Eva Maria" sort="Blumrich, Eva Maria" uniqKey="Blumrich E" first="Eva-Maria" last="Blumrich">Eva-Maria Blumrich</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, Bremen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, Bremen</wicri:regionArea><placeName><region type="land" nuts="3">Brême (Land)</region><settlement type="city">Brême</settlement></placeName></affiliation></author><author><name sortKey="Lourenco, Mychael V" sort="Lourenco, Mychael V" uniqKey="Lourenco M" first="Mychael V" last="Lourenco">Mychael V. Lourenco</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Joshi, Pooja" sort="Joshi, Pooja" uniqKey="Joshi P" first="Pooja" last="Joshi">Pooja Joshi</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR 1141, Robert Debre Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR 1141, Robert Debre Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hegemann, Regina U" sort="Hegemann, Regina U" uniqKey="Hegemann R" first="Regina U" last="Hegemann">Regina U. Hegemann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Brain Health Research Centre, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Psychology, Brain Health Research Centre, University of Otago, Dunedin</wicri:regionArea><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Jamwal, Sumit" sort="Jamwal, Sumit" uniqKey="Jamwal S" first="Sumit" last="Jamwal">Sumit Jamwal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab</wicri:regionArea><wicri:noRegion>Punjab</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Nilufar" sort="Ali, Nilufar" uniqKey="Ali N" first="Nilufar" last="Ali">Nilufar Ali</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Garcia Romero, Ezra Michelet" sort="Garcia Romero, Ezra Michelet" uniqKey="Garcia Romero E" first="Ezra Michelet" last="García Romero">Ezra Michelet García Romero</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Research in Chemogenomics, Medicinal Chemistry, University of Veracruz, Veracruz, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratory of Research in Chemogenomics, Medicinal Chemistry, University of Veracruz, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Sorabh" sort="Sharma, Sorabh" uniqKey="Sharma S" first="Sorabh" last="Sharma">Sorabh Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Neuropharmacology Division, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Neuropharmacology Division, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan</wicri:regionArea><wicri:noRegion>Rajasthan</wicri:noRegion></affiliation></author><author><name sortKey="Ghosh, Shampa" sort="Ghosh, Shampa" uniqKey="Ghosh S" first="Shampa" last="Ghosh">Shampa Ghosh</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Tarnaka, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Tarnaka, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Sinha, Jitendra K" sort="Sinha, Jitendra K" uniqKey="Sinha J" first="Jitendra K" last="Sinha">Jitendra K. Sinha</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Tarnaka, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Tarnaka, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Loke, Hannah" sort="Loke, Hannah" uniqKey="Loke H" first="Hannah" last="Loke">Hannah Loke</name><affiliation wicri:level="1"><nlm:affiliation>Hudson Institute of Medical Research, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hudson Institute of Medical Research, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Jain, Vishal" sort="Jain, Vishal" uniqKey="Jain V" first="Vishal" last="Jain">Vishal Jain</name><affiliation wicri:level="1"><nlm:affiliation>Defence Institute of Physiology and Allied Sciences, Delhi, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Defence Institute of Physiology and Allied Sciences, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Lepeta, Katarzyna" sort="Lepeta, Katarzyna" uniqKey="Lepeta K" first="Katarzyna" last="Lepeta">Katarzyna Lepeta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Salamian, Ahmad" sort="Salamian, Ahmad" uniqKey="Salamian A" first="Ahmad" last="Salamian">Ahmad Salamian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Mahima" sort="Sharma, Mahima" uniqKey="Sharma M" first="Mahima" last="Sharma">Mahima Sharma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Golpich, Mojtaba" sort="Golpich, Mojtaba" uniqKey="Golpich M" first="Mojtaba" last="Golpich">Mojtaba Golpich</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Kebangsaan Malaysia Medical Centre (HUKM), Cheras, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine, University Kebangsaan Malaysia Medical Centre (HUKM), Cheras, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Nawrotek, Katarzyna" sort="Nawrotek, Katarzyna" uniqKey="Nawrotek K" first="Katarzyna" last="Nawrotek">Katarzyna Nawrotek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Process Thermodynamics, Faculty of Process and Environmental Engineering, Lodz University of Technology, Lodz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Process Thermodynamics, Faculty of Process and Environmental Engineering, Lodz University of Technology, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Paidi, Ramesh K" sort="Paidi, Ramesh K" uniqKey="Paidi R" first="Ramesh K" last="Paidi">Ramesh K. Paidi</name><affiliation wicri:level="1"><nlm:affiliation>CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata</wicri:regionArea><wicri:noRegion>Kolkata</wicri:noRegion></affiliation></author><author><name sortKey="Shahidzadeh, Sheila M" sort="Shahidzadeh, Sheila M" uniqKey="Shahidzadeh S" first="Sheila M" last="Shahidzadeh">Sheila M. Shahidzadeh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Piermartiri, Tetsade" sort="Piermartiri, Tetsade" uniqKey="Piermartiri T" first="Tetsade" last="Piermartiri">Tetsade Piermartiri</name><affiliation wicri:level="1"><nlm:affiliation>Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina (UFSC), Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Amini, Elham" sort="Amini, Elham" uniqKey="Amini E" first="Elham" last="Amini">Elham Amini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Kebangsaan Malaysia Medical Centre (HUKM), Cheras, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine, University Kebangsaan Malaysia Medical Centre (HUKM), Cheras, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Pastor, Veronica" sort="Pastor, Veronica" uniqKey="Pastor V" first="Veronica" last="Pastor">Veronica Pastor</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Biología Celular y Neurociencia Prof. Eduardo De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Biología Celular y Neurociencia Prof. Eduardo De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Yvette" sort="Wilson, Yvette" uniqKey="Wilson Y" first="Yvette" last="Wilson">Yvette Wilson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Adeniyi, Philip A" sort="Adeniyi, Philip A" uniqKey="Adeniyi P" first="Philip A" last="Adeniyi">Philip A. Adeniyi</name><affiliation wicri:level="1"><nlm:affiliation>Cell Biology and Neurotoxicity Unit, Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado - Ekiti, Ekiti State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Cell Biology and Neurotoxicity Unit, Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado - Ekiti, Ekiti State</wicri:regionArea><wicri:noRegion>Ekiti State</wicri:noRegion></affiliation></author><author><name sortKey="Datusalia, Ashok K" sort="Datusalia, Ashok K" uniqKey="Datusalia A" first="Ashok K" last="Datusalia">Ashok K. Datusalia</name><affiliation wicri:level="1"><nlm:affiliation>National Brain Research Centre, Gurugram, Haryana, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>National Brain Research Centre, Gurugram, Haryana</wicri:regionArea><wicri:noRegion>Haryana</wicri:noRegion></affiliation></author><author><name sortKey="Vafadari, Benham" sort="Vafadari, Benham" uniqKey="Vafadari B" first="Benham" last="Vafadari">Benham Vafadari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Saini, Vedangana" sort="Saini, Vedangana" uniqKey="Saini V" first="Vedangana" last="Saini">Vedangana Saini</name><affiliation wicri:level="2"><nlm:affiliation>Department of Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska</wicri:regionArea><placeName><region type="state">Nebraska</region></placeName></affiliation></author><author><name sortKey="Suarez Pozos, Edna" sort="Suarez Pozos, Edna" uniqKey="Suarez Pozos E" first="Edna" last="Suárez-Pozos">Edna Suárez-Pozos</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Toxicología, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Toxicología</wicri:regionArea><wicri:noRegion>Toxicología</wicri:noRegion></affiliation></author><author><name sortKey="Kushwah, Neetu" sort="Kushwah, Neetu" uniqKey="Kushwah N" first="Neetu" last="Kushwah">Neetu Kushwah</name><affiliation wicri:level="1"><nlm:affiliation>Defence Institute of Physiology and Allied Sciences, Delhi, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Defence Institute of Physiology and Allied Sciences, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Fontanet, Paula" sort="Fontanet, Paula" uniqKey="Fontanet P" first="Paula" last="Fontanet">Paula Fontanet</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular and Cellular Neuroscience, Institute of Cellular Biology and Neuroscience (IBCN), CONICET-UBA, School of Medicine, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Division of Molecular and Cellular Neuroscience, Institute of Cellular Biology and Neuroscience (IBCN), CONICET-UBA, School of Medicine, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Turner, Anthony J" sort="Turner, Anthony J" uniqKey="Turner A" first="Anthony J" last="Turner">Anthony J. Turner</name><affiliation wicri:level="4"><nlm:affiliation>School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neurochemistry</title><idno type="eISSN">1471-4159</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation and long-term depression, respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity. This review originated from the first International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Alpbach, Austria (Sep 2016), and will use its curriculum and discussions as a framework to review some of the current knowledge in the field of synaptic plasticity. First, we describe the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages. We then outline the signaling cascades resulting in the synthesis of new plasticity-related proteins, which ultimately enable sustained changes in synaptic strength. Going beyond the traditional understanding of synaptic plasticity conceptualized by long-term potentiation and long-term depression, we discuss system-wide modifications and recently unveiled homeostatic mechanisms, such as synaptic scaling. Finally, we describe the neural circuits and synaptic plasticity mechanisms driving associative memory and motor learning. Evidence summarized in this review provides a current view of synaptic plasticity in its various forms, offers new insights into the underlying mechanisms and behavioral relevance, and provides directions for future research in the field of synaptic plasticity. Read the Editorial Highlight for this article on doi: 10.1111/jnc.14102.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Brésil</li><li>France</li><li>Inde</li><li>Malaisie</li><li>Mexique</li><li>Nigeria</li><li>Nouvelle-Zélande</li><li>Pologne</li><li>Royaume-Uni</li><li>Singapour</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>Brême (Land)</li><li>District de Basse-Franconie</li><li>District de Tübingen</li><li>Géorgie (États-Unis)</li><li>Nebraska</li><li>Victoria (État)</li><li>Yorkshire-et-Humber</li><li>État de New York</li><li>État de Rio de Janeiro</li><li>Île-de-France</li></region><settlement><li>Brême</li><li>Leeds</li><li>Melbourne</li><li>Paris</li><li>Rio de Janeiro</li><li>Tübingen</li><li>Wurtzbourg</li></settlement><orgName><li>Université de Leeds</li><li>Université de Melbourne</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Schaefer, Natascha" sort="Schaefer, Natascha" uniqKey="Schaefer N" first="Natascha" last="Schaefer">Natascha Schaefer</name></region><name sortKey="Blumrich, Eva Maria" sort="Blumrich, Eva Maria" uniqKey="Blumrich E" first="Eva-Maria" last="Blumrich">Eva-Maria Blumrich</name><name sortKey="Rotermund, Carola" sort="Rotermund, Carola" uniqKey="Rotermund C" first="Carola" last="Rotermund">Carola Rotermund</name></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Lourenco, Mychael V" sort="Lourenco, Mychael V" uniqKey="Lourenco M" first="Mychael V" last="Lourenco">Mychael V. 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Adeniyi</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Turner, Anthony J" sort="Turner, Anthony J" uniqKey="Turner A" first="Anthony J" last="Turner">Anthony J. Turner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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